Ultrastructural Study of Cadmium Effects on Photoreceptors and Ganglionic Cells of Retinal Layer in Mice Embryo

Purpose: In this study, TEM was used to asses the ultra structural effects of Cd on Photoreceptor and Ganglionic cells of mouce retinal layer. Materials and Methods: 30 mice hi1Vebeen used in three groups (experimental I, II & control). On 9th day of gestation, experimental groups have received a single IP injection of Cadmium- chlorid (Cd C12) solution in saline, 3 mg/kg and 5 mg/kg respectively and control group received only distilled water. The mice were euthanized on day 15 of gestation. Specimens for TEM were prepared. Results: External fragment shortness of photoreceptors, apoptotic nuclei, heterochromatic nuclei, deletion of nucleous membrane, invisible nucleolus, and mitochondrial changes in apoptotic cells were observed in experimental groups. Conclusion: Cadmium exposure causes apoptotic changes in Photoreceptors and Ganglionic cells.